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Ein Forscher träufelt aus einer kleinen Pipette eine Flüssigkeit in ein Reagenzglas. Mehrere Reagenzgläser und ein Erlenmeyerkolben vorn rechts sind mit einer hellblauen, klaren Flüssigkeit gefüllt. Kopf und Schultern des Forschers sind nur unscharf im Hintergrund zu erkennen.

Research Group: Neuroendocrine Tumors (NETs)

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Research Projects:

Clinical Science

  • Clinical trials on new oral- and parenteral-active drugs
  • New treatment approaches in radioreceptor therapy
  • Local sclerotherapy in comparison with alternative treatments
  • Treatment of the carcinoid heart disease (Hedinger syndrome) with non-surgical/non-invasive procedures

Basic Science

  • Studies to improve the early detection of tumors by molecular imaging using optical and radioactive methods. Eligible candidate ligands for imaging are determined with the aid of a large number of defined fluorescence- or radioactive-labeled receptor ligands.
  • Studies to improve the understanding and treatment of carcinoid syndrome, Zollinger-Ellison syndrome and “hypoglycemic” syndrome: By the means of vesicular secretion analyzes and functional analyzes of channel- and receptor-proteins (e.g. GABA receptors, vesicular monoamine transporters, calcium and TRP channels, etc.)

Tumor Growth:

Creation of molecular fingerprints of individual tumors and use of the resulting knowledge of changed molecular parameters for the therapy and clinical practice.

Principal Investigators

Dr. med. Henning Jann

Senior Physician Neuroendocrine Tumors (NETs)

Dr. Henning Jann, Hepatology and Gastroenterology, Senior Specialist
Prof. Dr. med. Michael Sigal

Attending physician/W2 Professor; Lead Luminal Gastroenterology, Principal Investigator (Emmy Noether-Program)

Dr. Michael Sigal, Hepatologie und Gastroenterologie, Oberarzt/Arbeitsgruppenleiter Emmy Noether-Programm
Prof. Dr. med. Bertram Wiedenmann

Senior Professor / Head of the NET Research Unit |ENETS-Center of Excellence, Charité

Prof. Dr. med. Bertram Wiedenmann, Hepatology and Gastroenterology, Senior Professor / Head of the NET Research Unit | ENETS-Center of Excellence, Charité