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Ein Forscher träufelt aus einer kleinen Pipette eine Flüssigkeit in ein Reagenzglas. Mehrere Reagenzgläser und ein Erlenmeyerkolben vorn rechts sind mit einer hellblauen, klaren Flüssigkeit gefüllt. Kopf und Schultern des Forschers sind nur unscharf im Hintergrund zu erkennen.

Luminal Gastroenterology

Luminal gastroenterology deals with immune-mediated, infectious and malignant diseases of the stomach and intestine. The focus of our research is the epithelium, i.e. the cell barrier that represents the border to the environment. We investigate how the interplay of external influences (e.g. nutrition, microbiome, pathogenic bacteria) and internal influences (growth factors,inflammatory mediators) affect the behavior of the epithelium. This knowledge will help to understand the pathogenesis of chronic inflammatory and malignant diseases of the stomach and intestine and to develop new therapeutic approaches.

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Scientific questions

  • Development of new primary model systems to decipher intercellular communication in the stomach and intestine
  • Systems biology of inflammatory and malignant processes in the stomach and intestine
  • Influence of bacteria on the development of chronic inflammatory and malignant gastrointestinal diseases

Funding

  • WILL FOUNDATION, 2012-2013
  • DFG Sachbeihilfe, 2016-2019
  • BIH Clinician Scientist Program, 2016-2019
  • DFG SPP Intestinal Microbiota, 2016-2019
  • DFG Emmy Noether Group, 2019-2025
  • EC3R (Einstein Center 3R)
  • ERC Starting Grant REVERT, 2023-2028
  • PACE Therapy, BMBF, 2022-2025

Team Leader

Prof. Dr. med. Michael Sigal

Senior physician/W2 Professor; Lead Luminal Gastroenterology, Principal Investigator (Emmy Noether-Program)

Prof. Dr. Michael Sigal, Hepatology and Gastroenterology, Senior Pysician/ Group leader Emmy Noether-Programme

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