Luminal gastroenterology deals with immune-mediated, infectious and malignant diseases of the stomach and intestine. The focus of our research is the epithelium, i.e. the cell barrier that represents the border to the environment. We investigate how the interplay of external influences (e.g. nutrition, microbiome, pathogenic bacteria) and internal influences (growth factors,inflammatory mediators) affect the behavior of the epithelium. This knowledge will help to understand the pathogenesis of chronic inflammatory and malignant diseases of the stomach and intestine and to develop new therapeutic approaches.
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- Development of new primary model systems to decipher intercellular communication in the stomach and intestine
- Systems biology of inflammatory and malignant processes in the stomach and intestine
- Influence of bacteria on the development of chronic inflammatory and malignant gastrointestinal diseases