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Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Campus Virchow-Klinikum, Forschungsbereich

Intestinal Barrier in chronic bowel diseases

Chronic intestinal failure is a rare disease entity that can be caused by a loss of bowel length (short bowel syndrome, SBS) or by functional disorders of the mucosa or motility, especially in the small intestine. Irreversible chronic intestinal failure is often accompanied by the need for total parenteral nutrition (PN). An essential part of the therapy is to restore part of the functionality of the residual intestine and thus improve the patient's quality of life.

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Research Focus

Regulation of intestinal epithelial regeneration, barrier function and immune cell activation in chronic intestinal diseases (IntestiReg)


  • SHIRE „Predictive Potential of Biomarkers of Intestinal Barrier Function for Therapeutic Management with Teduglutide in Patients with Short Bowel Syndrome”

Principal Investigators

Dr. rer. nat. Janine Büttner

Scientific staff/Lab management CCM

Standard-Porträt "Person, neutral"
Dr. med. Anja Schirbel

Visiting Researcher