Research Group: Hepato-gastrointestinal Inflammatory Mechanisms

Inflammatory mechanisms and cell death are critical elements in the development of acute and chronic inflammation of the liver and gastrointestinal tract. The research focus of the group is the investigation of the NLRP3 inflammasome and signaling pathways based on it in the pathogenesis of inflammatory diseases in the liver and the GI tract. The research goal is to investigate molecular and cellular mechanisms as well as interactions and to identify therapeutic and diagnostic targets based on them.

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Research Focus

Hepatobiliärer FSP
  1. Hepatobiliary research focus:Experimental-translational-clinical research on hepatobiliary inflammatory mechanisms
  2. Intestinal research focus:Inflammasome in the pathogenesis of inflammatory diseases in the liver and gastrointestinal (GI) tract
  3. Clinical-translational research focus:Translational studies on patients with clinical pictures showing hepato-gastrointestinal inflammation

These three research focuses (FSP) - hepatobiliary, intestinal and clinical-translational - enable a comprehensive investigation of hepato-gastrointestinal inflammatory mechanisms.Resources, techniques and interactions with other research groups can be used optimally.

Financial Support:

  • DFG (German Research Foundation) - Individual research grants
  • SFB / TRR57 (Collaborative Research Centre) Organ Fibrosis, DFG
  • Deutsche Krebshilfe (German Cancer Aid)
  • NIAAA – National Institute on Alcohol Abuse and Alcoholism

Team Leader

Prof. Dr. med. Alexander Wree

W2 Professor for Hepato-gastrointestinal Inflammatory Mechanisms

Prof. Dr. med. Alexander Wree, Hepatologie und Gastroenterologie, Oberarzt