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Research Group: Cellular Interactions in Liver Injuries and Regeneration

The liver is a vital and complex organ, with potent roles in controlling individuals’ metabolism and systemic immune response in normal condition, but also upon liver disease. Importantly, the liver is populated by multiple cell types; including hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells, and cholangiocytes, as well as very diverse myeloid and lymphoid immune cell populations. Because of such functional and cellular diversity, we study liver homeostasis, injury and repair using elaborate multiplexed approaches (either in situ or in vitro) made possible by recent technological advances.

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Research Focus

AG Zelluläre Interaktionen in Leberschädigung

Cells of different ontology or activation status communicate with each other through multiple pathways in a (patho-)physiological context. We believe a better understanding of the complex liver microenvironment and intercellular networks is key to unravelling novel and therapeutically relevant targets for disease treatment. We are more specifically exploring multiplex immunostaining coupled with digital image analysis, and liver-on-a-chip models using primary cells (see below).


Liver diseases:

  • Non-alcoholic fatty liver disease (NAFLD)
  • Non-alcoholic steatohepatitis (NASH)
  • Primary Sclerosing Cholangitis (PSC)
  • Cholangiocarcinoma
  • Gut-liver axis
  • Alcohol Use Disorders (AUD)

In situ immune microenvironment characterization:

  • Multiplex Immunohistochemistry
  • Digital microscopy image analysis
  • Imaging Cytometry

In vitro models:

  • Liver-on-a-chip
  • Primary liver cell isolation
  • Gene interference



Team Leader

Team Members